Single-dose vials. PDF Extravasation/Infiltration Management Chart - Johns Hopkins University Available from: [place unknown]: [publisher unknown]; 2018. It is soluble in water, methanol, and chloroform. The use of intravenous diltiazem for control of ventricular response in patients with supraventricular arrhythmias should be undertaken with caution when the patient is compromised hemodynamically. In terms of cancer therapy, extravasation refers to the inadvertent infiltration of chemotherapeutic drugs in the tissues surrounding the IV site. These contents are derived from authors experiences and the references [1-21]. w !1AQaq"2B #3Rbr show all 12 brands The intravenous LD50's in mice and rats were 60 and 38 mg/kg, respectively. If these agents are to be administered concurrently, cyclosporine concentrations should be monitored, especially when diltiazem therapy is initiated, adjusted or discontinued. %PDF-1.6 % High blood pressure adds to the workload of the heart and arteries. 0000006222 00000 n 0000024987 00000 n Because errors associated with IV administration can result in fatal or life-threatening outcomes, administration of IV fluids and medications can be a high-risk, with adverse outcomes potentially leading to malpractice claims. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota. The drug prevents the recurrence of life-threatening ventricular arrhythmias and. Special drug management for care of the extravasation. High blood pressure often has no symptoms. Langer SW. Extravasation of chemotherapy. severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling. You may report side effects to FDA at 1-800-FDA-1088. Barton-Burke M, Wilkes GM, Ingwersen KC, Bean CK, Berg D. Cancer chemotherapy: a nursing process approach. Clinical studies of diltiazem did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Experience in the use of antiarrhythmic agents following maintenance infusion of diltiazem hydrochloride injection is limited. The heart rate reduction may last from 1 - 3 hours. Diltiazem may impair your thinking or reactions. Patients with low body weights should be dosed on a mg/kg basis. 512 0 obj <> endobj hbbd```b``= "ro) "5" `LBT80yLHf) 8, EA! For either indication and particularly when employing continuous intravenous infusion, the setting should include continuous monitoring of the ECG and frequent measurement of blood pressure. As a library, NLM provides access to scientific literature. HHS Vulnerability Disclosure, Help Subsequent dose adjustments may be necessary during coadministration, and should be based on clinical assessment. Although clear benefit has not been demonstrated with thermal applications, it remains a standard supportive care. Diltiazem exhibits frequency (use) dependent effects on AV nodal conduction such that it may selectively reduce the heart rate during tachycardias involving the AV node with little or no effect on normal AV nodal conduction at normal heart rates.
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